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Dear Friends of B4B,

It has been almost a year since we bid farewell to our dear friend and valued member, Dr. David Begley, the Vice President and Co-Founder of the Brains for Brain Foundation. His absence continues to be deeply felt within our community, and in honor of his memory, we are organizing a special celebration to mark the first anniversary of his passing and the restart of the Brains for Brain Foundation’s activities.

In the spirit of David’s vision and dedication, we aim to once again breathe life into the B4B initiative.

To this end, we are organizing a gathering that not only serves as a high-value scientific meeting but also as an opportunity to bring together all those who were close to David and his family. Through this event, we aspire to pay a fitting tribute to David’s memory and celebrate his lasting impact on our organization and the broader scientific community.

We are currently finalizing the program of this special meeting, which will take place at the Sidney Sussex College in Cambridge, UK, from September 9th to September 11th, 2024.

You can have a look at the draft programme here

 If you wish to attend the workshop, please get in touch with Mrs Paula Caprelli (p.caprelli@jazzitaly.com) as soon as possible in order for us to be able to register your presence and predispose the logistics.

For general enquiries or any additional required information, please get in touch with Dr. Cinzia Maria Bellettato (c.bellettato@gmail.com)

We look forward to seeing you in September as we come together to honour the memory of Dr. David Begley and revive the important work of the Brains for Brain Foundation.

The great unforgettable Prof. David Begley PhD passed away last July 6, 2023. Though his physical presence is no longer with us, his unwavering spirit and enthusiasm continue to inspire and drive our organization forward.

As planned with Prof. Begley just before his passing, the Brains for Brain Foundation remains steadfastly committed to fostering research among young scientists. The foundation is particularly focused on encouraging these researchers to unravel the pathophysiology of Lysosomal Diseases’ neuronopathic phenotypes and search for therapies that can cross the blood-brain barrier – a cause that was dear to David’s heart.

In honour of Prof. Begley’s remarkable legacy and contributions, the Brains for Brain Foundation has established the prestigious David Begley Award. It is with great pleasure that we announce the inaugural recipient of this award, Ms. Chloé Dias, an outstanding PhD student in Prof. Jerome Ausseil’s lab at the University of Toulouse, France.

Ms. Dias was recognized for her groundbreaking work on “Microglia-derived extracellular vesicles promote neuropathology in Sanfilippo Syndrome,” which was presented at the 17th Symposium on Mucopolysaccharidosis and Related Diseases, which took place from April 4-7, 2024  in Würzburg, Germany, and that was aimed at discussing the latest information about MPS and related lysosomal storage.

The Brains for Brain Foundation extends its heartfelt congratulations to Ms. Chloé Dias, a promising young researcher who exemplifies the spirit of innovation and dedication that defined Prof. David Begley’s legacy. We are confident that her work will continue to inspire and propel the field of Mucopolysaccharidosis research forward, honouring the memory of our dear friend and colleague.

As we move forward without Prof. Begley’s physical presence, we are resolved to carry on his vision and ensure that the Brains for Brain Foundation remains a beacon of hope and a driving force in the pursuit of treatments and cures for Lysosomal Diseases. Through initiatives like the David Begley Award, we will continue to nurture the next generation of researchers and innovators, empowering them to follow in David’s footsteps and make a lasting impact on the world.

The Brains for Brain Foundation is organising its annual workshop that will be held at Sidney Sussex College in Cambridge, UK, on 9-11 September 2024.

The program will feature both scientific and strategic sessions, covering various aspects of CNS involvement in Lysosomal Storage Disorders, updates on the progress of the B4B Core Projects, and discussions on attracting EU and private funds to support the Foundation’s research initiatives.

The workshop will also represent an opportunity to pay tribute to the memory of Dr. David Begley, the vice president and co-founder of the Brains for Brain Foundation.

If you wish to attend the workshop, please get in touch with Mrs Paula Caprelli (p.caprelli@jazzitaly.com) as soon as possible in order for us to be able to register your presence and predispose the logistics.

For general enquiries or any additional required information, please get in touch with Dr. Cinzia Maria Bellettato (c.bellettato@gmail.com)

It is with profound sadness that we announce the passing of our dear friend and esteemed colleague, Professor David Begley, PhD, on the evening of July 6, 2023. David was a towering figure in the world of pharmaceutical sciences and a tireless advocate for advancing research into the treatment of central nervous system (CNS) diseases.

David’s distinguished career spanned decades, during which he made invaluable contributions to our understanding of the blood-brain barrier (BBB) and its role in drug delivery to the CNS. As a Senior Lecturer in Physiology at King’s College London, he led a laboratory within the Institute of Pharmaceutical Sciences that was at the forefront of this critical area of research.

David’s expertise and impact extended far beyond the walls of King’s College. He was the Friedrich Mertz Stiftungsgast professor at the Johann Wolfgang Goethe-Universität in Frankfurt for the academic year 1997-1998 and was a visiting Academic in Residence at GlaxoSmithKline from 2005 to 2007. He also served as the Organizer and Chairman of the prestigious Gordon Conference on “Barriers of the CNS” held in New Hampshire in 2002.

Throughout his distinguished career, David was a constituent part of the Pharmaceutical Sciences Research Division, where he was recognized as one of the world’s leading authorities on the function of the blood-brain barrier. His groundbreaking work contributed greatly to our understanding of the effects of storage and secondary effects of storage on the BBB, which was instrumental in advancing the field of lysosomal storage diseases.

In addition to his academic pursuits, David was a co-founder of the Brains for Brain Foundation in 2007, where he worked tirelessly to network basic BBB scientists, neurophysiologists, and neurologists to uncover new ways to deliver drugs across the blood-brain barrier. This collaborative effort was a testament to David’s commitment to driving innovation and improving patient outcomes.

David’s loss is deeply felt by all who had the privilege of knowing him. His extraordinary scientific contributions, his generosity, and his unwavering humanity will be sorely missed. As we mourn the passing of this remarkable individual, we are reminded of the indelible mark he has left on the field of pharmaceutical sciences and the lives he has touched.

Ciao, David. Thank you for your friendship, your passion, and your relentless pursuit of scientific excellence. Your legacy will continue to inspire generations of researchers to come.